Targeting Chromatin Disruption: Transcription Regulators that Acetylate Histones
نویسندگان
چکیده
An intimate relationship exists between the transcriptional machinery and the chromosomal environment within which it functions. The histones package all chromosomal DNA into nucleosomes, yet mutations in individual histones have specific consequences for the expression of particular genes (Grunstein et al., 1992; Kruger et al., 1995). How can general DNA packaging proteins contribute to the specific regulation of transcription? One mechanism is to target regulatory proteins that modify chromatin structure to particular promoters.
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عنوان ژورنال:
- Cell
دوره 84 شماره
صفحات -
تاریخ انتشار 1996